Unknown,Transcriptomics,Genomics,Proteomics

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RERG is a novel ras-related, estrogen-regulated and growth-inhibitory gene in breast cancer


ABSTRACT: Using microarray analysis, we identified a unique ras superfamily gene, termed RERG (ras-related and estrogen-regulated growth inhibitor), whose expression was decreased or lost in a significant percentage of primary human breast tumors that show a poor clinical prognosis. Importantly, high RERG expression correlated with expression of a set of genes that define a breast tumor subtype that is estrogen receptor-positive and associated with a slow rate of tumor cell proliferation and a favorable prognosis for these cancer patients. RERG mRNA expression was induced rapidly in MCF-7 cells stimulated by beta-estradiol and repressed by tamoxifen treatment. Like Ras, RERG protein exhibited intrinsic GDP/GTP binding and GTP hydrolysis activity. Unlike Ras proteins, RERG lacks a known recognition signal for COOH-terminal prenylation and was localized primarily in the cytoplasm. Expression of RERG protein in MCF-7 breast carcinoma cells resulted in a significant inhibition of both anchorage-dependent and anchorage-independent growth in vitro and inhibited tumor formation in nude mice. These features of RERG are strikingly different from most Ras superfamily GTP-binding pro-teins and suggest that the loss of RERG expression may contribute to breast tumorigenesis. Groups of assays that are related as part of a time series. Computed

ORGANISM(S): Homo sapiens

SUBMITTER: Charles Perou 

PROVIDER: E-GEOD-2987 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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RERG is a novel ras-related, estrogen-regulated and growth-inhibitory gene in breast cancer.

Finlin B S BS   Gau C L CL   Murphy G A GA   Shao H H   Kimel T T   Seitz R S RS   Chiu Y F YF   Botstein D D   Brown P O PO   Der C J CJ   Tamanoi F F   Andres D A DA   Perou C M CM  

The Journal of biological chemistry 20010831 45


Using microarray analysis, we identified a unique ras superfamily gene, termed RERG (ras-related and estrogen-regulated growth inhibitor), whose expression was decreased or lost in a significant percentage of primary human breast tumors that show a poor clinical prognosis. Importantly, high RERG expression correlated with expression of a set of genes that define a breast tumor subtype that is estrogen receptor-positive and associated with a slow rate of tumor cell proliferation and a favorable p  ...[more]

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