Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Charles Perou
PROVIDER: E-GEOD-2987 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Finlin B S BS Gau C L CL Murphy G A GA Shao H H Kimel T T Seitz R S RS Chiu Y F YF Botstein D D Brown P O PO Der C J CJ Tamanoi F F Andres D A DA Perou C M CM
The Journal of biological chemistry 20010831 45
Using microarray analysis, we identified a unique ras superfamily gene, termed RERG (ras-related and estrogen-regulated growth inhibitor), whose expression was decreased or lost in a significant percentage of primary human breast tumors that show a poor clinical prognosis. Importantly, high RERG expression correlated with expression of a set of genes that define a breast tumor subtype that is estrogen receptor-positive and associated with a slow rate of tumor cell proliferation and a favorable p ...[more]