S. fradiae WT and KOS155-3C R5/No Glucose 02/09/03
Ontology highlight
ABSTRACT:
ORGANISM(S): Streptomyces coelicolor
SUBMITTER: Amy Lum
PROVIDER: E-GEOD-2995 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Reverse engineering of industrial pharmaceutical-producing actinomycete strains using DNA microarrays.
Lum Amy M AM Huang Jianqiang J Hutchinson C Richard CR Kao Camilla M CM
Metabolic engineering 20040701 3
Transcript levels in production cultures of wildtype and classically improved strains of the actinomycete bacteria Saccharopolyspora erythraea and Streptomyces fradiae were monitored using microarrays of the sequenced actinomycete S. coelicolor. Sac. erythraea and S. fradiae synthesize the polyketide antibiotics erythromycin and tylosin, respectively, and the classically improved strains contain unknown overproduction mutations. The Sac. erythraea overproducer was found to express the entire 56- ...[more]
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