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Gene expression analysis of prostate tumors arisen in TRAMP mice in which mast cells are pharmacologically stabilized or genetically ablated.

ABSTRACT: Analysis of gene expression of prostate tumors arisen in TRAMP mice in which mast cells are pharmacologically stabilized or genetically ablated.The hypothesis tested in the present study was that mast cells inhibition or absence impacted prostate tumor development and histotype. Results demonstrate that prostate tumors arisen in TRAMP mice in which mast cells are pharmacologically stabilized or genetically ablated have a neuroendocrine signature. Total RNA obtained from prostate tumors from 24 wks old TRAMP mice chronically treated with sodium chromoglycate (cromolyn) since 8 wks of age, and from 24 wks old TRAMP KitW-sh mice, compared to untreated 30 wks old TRAMP mice and to non tumoral prostates

ORGANISM(S): Mus musculus

SUBMITTER: Paola Pittoni

PROVIDER: E-GEOD-29956 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Mast cell targeting hampers prostate adenocarcinoma development but promotes the occurrence of highly malignant neuroendocrine cancers.

Project description:This SuperSeries is composed of the following subset Series: GSE29956: Gene expression analysis of prostate tumors arisen in TRAMP mice in which mast cells are pharmacologically stabilized or genetically ablated. GSE29957: Gene expression analysis of 2 different prostate tumor cell lines isolated from 30 wks old TRAMP mice compared to normal prostate Refer to individual Series

2011-06-15 | E-GEOD-29958 | biostudies-arrayexpress

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Project description:Gene expression analysis of prostate tumors arisen in TRAMP mice in which mast cells are pharmacologically stabilized or genetically ablated.

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