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ChIP-seq of Ezh2 and H3K27me3 in E12.5 heart apex

ABSTRACT: Ezh2 and H3K27me3 binding sites in E12.5 heart apex PRC2 binding sites in wild type cardiomyocytes

ORGANISM(S): Mus musculus

SUBMITTER: Michael Hsing

PROVIDER: E-GEOD-29994 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Polycomb repressive complex 2 regulates normal development of the mouse heart.

He Aibin A Ma Qing Q Cao Jingjing J von Gise Alexander A Zhou Pingzhu P Xie Huafeng H Zhang Bing B Hsing Michael M Christodoulou Danos C DC Cahan Patrick P Daley George Q GQ Kong Sek Won SW Orkin Stuart H SH Seidman Christine E CE Seidman Jonathan G JG Pu William T WT

Circulation research 20111208 3

<h4>Rationale</h4>Epigenetic marks are crucial for organogenesis, but their role in heart development is poorly understood. Polycomb repressive complex 2 (PRC2) trimethylates histone H3 at lysine 27, which establishes H3K27me3 repressive epigenetic marks that promote tissue-specific differentiation by silencing ectopic gene programs.<h4>Objective</h4>We studied the function of PRC2 in murine heart development using a tissue-restricted conditional inactivation strategy.<h4>Methods and results</h4 ...[more]

PMID: 22158708

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