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Gene expression changes during Type 1 diabetes pathogenesis

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Due to privacy concerns, the SNP data is not available with unrestricted access. Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Henna KallionpM-CM-$M-CM-$

PROVIDER: E-GEOD-30211 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Innate immune activity is detected prior to seroconversion in children with HLA-conferred type 1 diabetes susceptibility.

Kallionpää Henna H Elo Laura L LL Laajala Essi E Mykkänen Juha J Ricaño-Ponce Isis I Vaarma Matti M Laajala Teemu D TD Hyöty Heikki H Ilonen Jorma J Veijola Riitta R Simell Tuula T Wijmenga Cisca C Knip Mikael M Lähdesmäki Harri H Simell Olli O Lahesmaa Riitta R

Diabetes 20140218 7

The insult leading to autoantibody development in children who will progress to develop type 1 diabetes (T1D) has remained elusive. To investigate the genes and molecular pathways in the pathogenesis of this disease, we performed genome-wide transcriptomics analysis on a unique series of prospective whole-blood RNA samples from at-risk children collected in the Finnish Type 1 Diabetes Prediction and Prevention study. We studied 28 autoantibody-positive children, out of which 22 progressed to cli ...[more]

PMID: 24550192

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