Expression analysis of eu-miR-155 transgenic mice B-cells.
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Sukhinder Sandhu
PROVIDER: E-GEOD-30248 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
miR-155 targets histone deacetylase 4 (HDAC4) and impairs transcriptional activity of B-cell lymphoma 6 (BCL6) in the Eμ-miR-155 transgenic mouse model.
Sandhu Sukhinder K SK Volinia Stefano S Costinean Stefan S Galasso Marco M Neinast Reid R Santhanam Ramasamy R Parthun Mark R MR Perrotti Danilo D Marcucci Guido G Garzon Ramiro R Croce Carlo M CM
Proceedings of the National Academy of Sciences of the United States of America 20121119 49
Multiple studies have established that microRNAs (miRNAs) are involved in the initiation and progression of cancer. Notably, miR-155 is one of the most overexpressed miRNAs in several solid and hematological malignancies. Ectopic miR-155 expression in mice B cells (Eμ-miR-155 transgenic mice) has been shown to induce pre-B-cell proliferation followed by high-grade lymphoma/leukemia. Loss of miR-155 in mice resulted in impaired immunity due to defective T-cell-mediated immune response. Here we pr ...[more]
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