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Unknown,Transcriptomics,Genomics,Proteomics

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Transcriptional network governed by IRF8 and/or PU.1 in germinal center B cells

ABSTRACT: This SuperSeries is composed of the following subset Series: GSE30357: Chip-chip from human diffuse large B cell lymphoma cell lines with IRF8 GSE30358: Mouse B cell lymphoma cell lines:IRF8 knockdown cells vs. Control GSE30519: Chip-chip from mouse diffuse large B cell lymphoma cell lines with IRF8 GSE30520: Chip-chip from mouse diffuse large B cell lymphoma cell lines with PU.1 Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Dong-Mi Shin

PROVIDER: E-GEOD-30359 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Chip-chip from human diffuse large B cell lymphoma cell lines with IRF8

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Project description:IRF8, a transcriptional factor, has the heightened expression in germinal center(GC) B cell and GC-origin B cell lymphoma. To identify IRF8 direct targets in GC B cells, ChIP-chip ananlysis was done in three different GC-origin diffuse large B cell lymphoma cell lines. IRF8-negative cell lines, MMS1, was also used as a negatvie control. IRF8 ChIP in three different cell lines (ODH1, VAL and LY1:high level of IRF8) and in one negative control cell lines (MMS1:negatvie for IRF8). Total four different samples. One sample per a set of two arrays (promoter1 and promoter2).

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