Unknown,Transcriptomics,Genomics,Proteomics

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Gene expression in cellular compartments of Aplysia motor neurons


ABSTRACT: Whole genome transcriptional profiling is used to compare ESTs found in cell bodies and processes of Aplysia motor neurons RNA samples derived from cell bodies or processes of Aplysia single cultured motor neurons were hybridized to custom Aplysia EST microarrays. Two-condition experiment; four biological replicates for each condition were reciprocally hybridized on each two-color array

ORGANISM(S): Aplysia californica

SUBMITTER: Sergey Kalachikov 

PROVIDER: E-GEOD-30387 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


Here we describe a strategy designed to identify RNAs that are actively transported to synapses during learning. Our approach is based on the characterization of RNA transport complexes carried by molecular motor kinesin. Using this strategy in Aplysia, we have identified 5,657 unique sequences consisting of both coding and noncoding RNAs from the CNS. Several of these RNAs have key roles in the maintenance of synaptic function and growth. One of these RNAs, myosin heavy chain, is critical in pr  ...[more]

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