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Unknown,Transcriptomics,Genomics,Proteomics

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CopY Mutant compared to D39 wild-type

ABSTRACT: Comparison of the Streptococcus pneumoniae D39 copY-stop mutant compared to D39 wild type in CDM without added copper One condition design comparision of two strains including a dye swap

ORGANISM(S): Streptococcus pneumoniae D39

SUBMITTER: Sulman Shafeeq

PROVIDER: E-GEOD-30414 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The cop operon is required for copper homeostasis and contributes to virulence in Streptococcus pneumoniae.

Shafeeq Sulman S Yesilkaya Hasan H Kloosterman Tomas G TG Narayanan Geetha G Wandel Michal M Andrew Peter W PW Kuipers Oscar P OP Morrissey Julie A JA

Molecular microbiology 20110719 5

High levels of copper are toxic and therefore bacteria must limit free intracellular levels to prevent cellular damage. In this study, we show that a number of pneumococcal genes are differentially regulated by copper, including an operon encoding a CopY regulator, a protein of unknown function (CupA) and a P1-type ATPase, CopA, which is conserved in all sequenced Streptococcus pneumoniae strains. Transcriptional analysis demonstrated that the cop operon is induced by copper in vitro, repressed ...[more]

PMID: 21736642

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