Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Antonio Di Cristofano
PROVIDER: E-GEOD-30427 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Antico Arciuch Valeria G VG Russo Marika A MA Dima Mariavittoria M Kang Kristy S KS Dasrath Florence F Liao Xiao-Hui XH Refetoff Samuel S Montagna Cristina C Di Cristofano Antonio A
Oncotarget 20111201 12
Anaplastic thyroid carcinoma (ATC) is the most aggressive form of thyroid cancer, and often derives from pre-existing well-differentiated tumors. Despite a relatively low prevalence, it accounts for a disproportionate number of thyroid cancer-related deaths, due to its resistance to any therapeutic approach. Here we describe the first mouse model of ATC, obtained by combining in the mouse thyroid follicular cells two molecular hallmarks of human ATC: activation of PI3K (via Pten deletion) and in ...[more]