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Expression analysis of mouse thyroid tumors


ABSTRACT: Anaplastic thyroid carcinoma (ATC) is the most aggressive form of thyroid cancer, and often derives from pre-existing well-differentiated tumors. We have engineered the first mouse model of ATC by combining in the mouse thyroid follicular cells two molecular hallmarks of human ATC: activation of PI3K (via Pten deletion) and inactivation of p53. By 9 months of age, over 75% of the compound mutant mice develop aggressive, undifferentiated thyroid tumors that evolve from pre-existing follicular hyperplasia and carcinoma. These tumors display all the features of their human counterpart, including pleomorphism, epithelial-mesenchymal transition, aneuploidy, local invasion and distant metastases. We have performed expression profiling of thyroids from control, single mutants, compound mutants, follicular tumors from Pten-/- mice, and anaplastic tumors from Pten, p53-/- mice.

ORGANISM(S): Mus musculus

SUBMITTER: Antonio Di Cristofano 

PROVIDER: E-GEOD-30427 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Thyrocyte-specific inactivation of p53 and Pten results in anaplastic thyroid carcinomas faithfully recapitulating human tumors.

Antico Arciuch Valeria G VG   Russo Marika A MA   Dima Mariavittoria M   Kang Kristy S KS   Dasrath Florence F   Liao Xiao-Hui XH   Refetoff Samuel S   Montagna Cristina C   Di Cristofano Antonio A  

Oncotarget 20111201 12


Anaplastic thyroid carcinoma (ATC) is the most aggressive form of thyroid cancer, and often derives from pre-existing well-differentiated tumors. Despite a relatively low prevalence, it accounts for a disproportionate number of thyroid cancer-related deaths, due to its resistance to any therapeutic approach. Here we describe the first mouse model of ATC, obtained by combining in the mouse thyroid follicular cells two molecular hallmarks of human ATC: activation of PI3K (via Pten deletion) and in  ...[more]

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