Transcriptomics

Dataset Information

0

Expression analysis of mouse thyroid tumors


ABSTRACT: Anaplastic thyroid carcinoma (ATC) is the most aggressive form of thyroid cancer, and often derives from pre-existing well-differentiated tumors. We have engineered the first mouse model of ATC by combining in the mouse thyroid follicular cells two molecular hallmarks of human ATC: activation of PI3K (via Pten deletion) and inactivation of p53. By 9 months of age, over 75% of the compound mutant mice develop aggressive, undifferentiated thyroid tumors that evolve from pre-existing follicular hyperplasia and carcinoma. These tumors display all the features of their human counterpart, including pleomorphism, epithelial-mesenchymal transition, aneuploidy, local invasion and distant metastases.

ORGANISM(S): Mus musculus

PROVIDER: GSE30427 | GEO | 2012/03/14

SECONDARY ACCESSION(S): PRJNA143527

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2012-03-14 | E-GEOD-30427 | biostudies-arrayexpress
2014-04-02 | E-GEOD-55933 | biostudies-arrayexpress
2024-04-08 | PXD044110 | Pride
2022-09-08 | GSE212703 | GEO
2014-04-02 | GSE55933 | GEO
2020-07-07 | GSE126728 | GEO
2020-07-07 | GSE126698 | GEO
2022-07-22 | GSE207677 | GEO
2007-09-21 | GSE9115 | GEO
2016-11-30 | GSE85457 | GEO