Colorectal Cancer Cells
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Keyan Salari
PROVIDER: E-GEOD-30475 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
CDX2 is an amplified lineage-survival oncogene in colorectal cancer.
Salari Keyan K Spulak Mary E ME Cuff Justin J Forster Andrew D AD Giacomini Craig P CP Huang Stephanie S Ko Melissa E ME Lin Albert Y AY van de Rijn Matt M Pollack Jonathan R JR
Proceedings of the National Academy of Sciences of the United States of America 20121029 46
The mutational activation of oncogenes drives cancer development and progression. Classic oncogenes, such as MYC and RAS, are active across many different cancer types. In contrast, "lineage-survival" oncogenes represent a distinct and emerging class typically comprising transcriptional regulators of a specific cell lineage that, when deregulated, support the proliferation and survival of cancers derived from that lineage. Here, in a large collection of colorectal cancer cell lines and tumors, w ...[more]
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