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MiRNA signatures of multiple endothelial cell types grown in culture

ABSTRACT: This experiment explored what miRNA differences and similarities exist between endothelial cells obtained from different vascular beds. Seven different endothelial cell (EC) types were grown in basal conditions. RNA was harvested when cells were nearly confluent. miRNAs were evaluated for each EC type in biological replicates.

ORGANISM(S): Homo sapiens

SUBMITTER: Marc Halushka

PROVIDER: E-GEOD-30512 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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MicroRNA profiling of diverse endothelial cell types.

McCall Matthew N MN Kent Oliver A OA Yu Jianshi J Fox-Talbot Karen K Zaiman Ari L AL Halushka Marc K MK

BMC medical genomics 20111102

<h4>Background</h4>MicroRNAs are ~22-nt long regulatory RNAs that serve as critical modulators of post-transcriptional gene regulation. The diversity of miRNAs in endothelial cells (ECs) and the relationship of this diversity to epithelial and hematologic cells is unknown. We investigated the baseline miRNA signature of human ECs cultured from the aorta (HAEC), coronary artery (HCEC), umbilical vein (HUVEC), pulmonary artery (HPAEC), pulmonary microvasculature (HPMVEC), dermal microvasculature ( ...[more]

PMID: 22047531

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