Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Yin Lin
PROVIDER: E-GEOD-30518 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Miyazaki Masaki M Rivera Richard R RR Miyazaki Kazuko K Lin Yin C YC Agata Yasutoshi Y Murre Cornelis C
Nature immunology 20110821 10
It is established that the transcription factor E2A and its antagonist Id3 modulate the checkpoints consisting of the precursor to the T cell antigen receptor (pre-TCR) and the TCR. Here we demonstrate that Id3 expression was higher beyond the pre-TCR checkpoint, remained high in naive T cells and showed a bimodal pattern in the effector-memory population. We show how E2A promoted T lineage specification and how pre-TCR-mediated signaling affected E2A genome-wide occupancy. Thymi in Id3-deficien ...[more]