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Gene Expression data from human brain tumor or normal brain

ABSTRACT: Stem cells from various lineages have well known for its migration tendency toward glioma and become attractive vehicles to deliver therapeutic genes to brain tumors. However, which factors and mechanisms work in these function is not yet known. To identify those factors and mechanisms, we analyzed the brain tumor-specific gene expression profile using microarray analysis To identify genes that are differentially expressed, human brain tumor samples and normal brains were collected from brain tumor patients for RNA extraction and hybridization on Affymetrix microarrays. To obtain samples, we got patients consent to collect and analysis of sample. All of three normal brains (N2, N3, N4) and brain tumor, Gliobalstoma (T2), Ganglioglioma (T3) and shwannoma(T4), are used for experiment.

ORGANISM(S): Homo sapiens

SUBMITTER: Myung Ae Lee

PROVIDER: E-GEOD-30563 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Gene Expression data from human brain tumor or normal brain

Project description:Stem cells from various lineages have well known for its migration tendency toward glioma and become attractive vehicles to deliver therapeutic genes to brain tumors. However, which factors and mechanisms work in these function is not yet known. To identify those factors and mechanisms, we analyzed the brain tumor-specific gene expression profile using microarray analysis

2011-07-12 | GSE30563 | GEO

RNA seq to compare gene expression profiles between Npm1 WT and Npm1 knockdown cells

Project description:Mouse KrasG12D/P53-/-(KP) lung tumor cells were transfected with pLKO.1-Tet on-shNpm1-3(N3), pLKO.1-Tet on-shNpm1-4(N4) or pLKO.1-Tet on-shNpm1-5 (N5) and then selected by using 2ug/ml puromycin, to establish the 3 stable cell lines. These 3 stable cell lines (N3, N4 or N5) were treated with 100ng/ml Doxycline and then the total RNA of the treated and untreated cells were harvested for RNA seq.

2020-06-22 | GSE133555 | GEO

Gene expression of pediatric brain tumors- medulloblastoma and ependymoma

Project description:The aim of the study was to compare the level of gene expression in pediatric brain tumors of various degrees of malignancy.

2024-07-28 | E-MTAB-14259 | biostudies-arrayexpress

Cervical Tissue Long SAGE

Project description:16 Long SAGE libraries Keywords: Various degrees of cervical dysplasia Normal Cervical Tissue (N1, N2, N3, N4) CIN III, severe dysplasia cervical tissue (C1, C2, C3, C4, C5, C6) CIN I, mild dysplasia, cervical tissue (M1, M2, M3) CIN II, moderate dysplasia, cervical tissue (M4, M5, M6)

2008-02-18 | E-GEOD-7433 | biostudies-arrayexpress

ATV-TfR and ATV-CD98hc biodistribution in the mouse brain

Project description:We evaluated the distributions of transferrin receptor (TfR)- and CD98 heavy chain (CD98hc)-targeting antibody transport vehicles (ATVs) in mouse brain using systemically injected fluorescently tagged ATVs. Combining FACS sorting with scRNA-seq, we report the localization of ATV-TfR and ATV-CD98hc on brain endothelial cells and their unique distribution across parenchymal brain cells.

2024-10-02 | GSE262436 | GEO

Robotic vs Laparoscopic D3-D4 Lymphadenectomy for Colorectal Cancer

Project description:Approximately one third of patients with colorectal cancer are diagnosed as locally advanced stage with metastasis to N3 - N4 lymph nodes requiring a D3 - D4 lymphadenectomy. Our previous study has indicated that, by laparoscopic approach, the extended abdomino-iliac lymphadenectomy, the so-called D3-D4 lymph node dissection, could be performed with quick convalescence and similar oncologic efficacy for the treatment of advanced recto-sigmoid cancer with metastatic lesions over N3-N4 lymph nodes, as compared with traditional open surgery. In the present study, the investigators will further compare the oncologic and functional outcomes of robotic versus laparoscopic approach in performing such challenging surgical procedures for patients with advanced colorectal cancer requiring a D3-D4 lymphadenectomy through a randomized prospective clinical trial.

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Gene expression data from striatal regions of MPTP-intoxicated mouse brain by acupuncture

Project description:Acupuncture at acupoints GB34 and LR3 has been reported to inhibit nigrostriatal degeneration in parkinsonism models, yet the genes related to this preventive effect of acupuncture on the nigrostriatal dopaminergic system remain elusive. We investigated gene expression profile changes in the striatal region of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism models after acupuncture at the acupoints GB34 and LR3 C57BL/6 mice were divided into four experimental groups; â C: Control, â¡ M: MPTP-treatment only, â¢ MA: MPTP- and acupuncture-treatment at acupoints GB34 and LR3, â£ MNA: MPTP- and acupuncture-treatment at non-acupoints. Total RNA was isolated from two brains' striatal regions of each experimental group (4 experimental group Ã 2 samples of each experimental group = total 8 samples).

2010-10-23 | E-GEOD-24829 | biostudies-arrayexpress

Gene expression data from thalamic regions of MPTP-intoxicated mouse brain by acupuncture

Project description:Acupuncture stimulations at GB34 and LR3 inhibit the reduction of tyrosine hydroxylase in the nigrostriatal dopaminergic neurons in the parkinsonism animal models. Especially, behavioral tests showed that acupuncture stimulations improved the motor dysfunction in a previous study. The thalamus is a crucial area for the motor circuit and has been identified as one of the most markedly damaged areas in Parkinson’s disease (PD), so acupuncture stimulations might also have an effect on the thalamic damage. We investigated gene expression profile changes in the thalamic region of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism models after acupuncture at the acupoints GB34 and LR3 C57BL/6 mice were divided into four experimental groups; ① C: Control, ② M: MPTP-treatment only, ③ MA: MPTP- and acupuncture-treatment at acupoints GB34 and LR3, ④ MNA: MPTP- and acupuncture-treatment at non-acupoints. Total RNA was isolated from two brains' thalamic regions of each experimental group (4 experimental group × 2 samples of each experimental group = total 8 samples).

2012-01-18 | E-GEOD-35138 | biostudies-arrayexpress

Comparison of precocious and non-precocious salmon brain

Project description:The objective was to compare gene expression in salmon precocious and non-precocious parr brain tissue. Eight microarray hybridisations were carried out in total as part of this design. To compare brain samples total RNA from 10 individual brains (dissected of hypothalamus and pituitary) of precocious fish and 10 brains of non-precocious fish were pooled to give two pools each of five precocious (PA and PB) and non-precocious (NPA and NPB) brains. Each pool of precocious brains was compared in a dye swap experiment with each pool of non-precocious brains.

2010-05-16 | E-GEOD-16720 | biostudies-arrayexpress

Gene expression data from brain striatal and spinal cord regions of MPTP-intoxicated mouse following acupuncture

Project description:This SuperSeries is composed of the following subset Series: GSE24829: Gene expression data from striatal regions of MPTP-intoxicated mouse brain by acupuncture GSE24830: Gene expression data from cervical spinal cord regions of MPTP-intoxicated mouse by acupuncture Refer to individual Series

2010-10-23 | E-GEOD-24838 | biostudies-arrayexpress

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