Unknown,Transcriptomics,Genomics,Proteomics

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Burkholderia cepacia complex and cystic fibrosis (CF) patients


ABSTRACT: This SuperSeries is composed of the following subset Series: GSE28306: Expression data from Burkholderia multivorans cystic fibrosis clinical isolates GSE30402: Hybridization of Burkholderia multivorans D2095 and D2214 genomic DNA Refer to individual Series

ORGANISM(S): Burkholderia multivorans

SUBMITTER: Leonilde Moreira 

PROVIDER: E-GEOD-30568 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Mucoid morphotype variation of Burkholderia multivorans during chronic cystic fibrosis lung infection is correlated with changes in metabolism, motility, biofilm formation and virulence.

Silva Inês N IN   Ferreira Ana S AS   Becker Jörg D JD   Zlosnik James E A JEA   Speert David P DP   He Ji J   Mil-Homens Dalila D   Moreira Leonilde M LM  

Microbiology (Reading, England) 20110811 Pt 11


Burkholderia cepacia complex (Bcc) bacteria are opportunistic pathogens infecting hosts such as cystic fibrosis (CF) patients. Long-term Bcc infection of CF patients' airways has been associated with emergence of phenotypic variation. Here we studied two Burkholderia multivorans clonal isolates displaying different morphotypes from a chronically infected CF patient to evaluate trait development during lung infection. Expression profiling of mucoid D2095 and non-mucoid D2214 isolates revealed dec  ...[more]

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