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Transposon-mediated gene regulatory network rewiring contributed to the evolution of pregnancy in mammals

ABSTRACT: We report the gene expression profile of human endometriual stromal cells and armadillo endometrial samples We report the gene expression profile of human endometriual stromal cells and armadillo endometrial samples generated with Illumina GA2

ORGANISM(S): Homo sapiens

SUBMITTER: Vincent Lynch

PROVIDER: E-GEOD-30708 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Transposon-mediated rewiring of gene regulatory networks contributed to the evolution of pregnancy in mammals.

Lynch Vincent J VJ Leclerc Robert D RD May Gemma G Wagner Günter P GP

Nature genetics 20110925 11

A fundamental challenge in biology is explaining the origin of novel phenotypic characters such as new cell types; the molecular mechanisms that give rise to novelties are unclear. We explored the gene regulatory landscape of mammalian endometrial cells using comparative RNA-Seq and found that 1,532 genes were recruited into endometrial expression in placental mammals, indicating that the evolution of pregnancy was associated with a large-scale rewiring of the gene regulatory network. About 13% ...[more]

PMID: 21946353

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