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Transcription profiling of Drosophila Kc167 cells treaye with ecdysone and gamma irradiation to investigate ecdysone- and stress-induced expression profiles

ABSTRACT: Kc167 cells were mock-treated/treated with combinations of steroid hormone ecdysone and gamma-irradiation, and harvested. The expression profiles were determined using Affymetrix Drosophila Genechip 1 arrays. Comparisons between the sample groups allow the identification of genes with ecdysone- and/or radiation-responsive expression patterns. Experiment Overall Design: 1 set of control, ecdysone, gamma-irradiated, ecdysone + irradiated samples was analyzed.

ORGANISM(S): Drosophila melanogaster

SUBMITTER: John Abrams

PROVIDER: E-GEOD-3072 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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p53 directs focused genomic responses in Drosophila.

Akdemir F F Christich A A Sogame N N Chapo J J Abrams J M JM

Oncogene 20070219 36

p53 is a fundamental determinant of cancer susceptibility and other age-related pathologies. Similar to mammalian counterparts, Drosophila p53 integrates stress signals and elicits apoptotic responses that maintain genomic stability. To illuminate core-adaptive functions controlled by this gene family, we examined the Drosophila p53 regulatory network at a genomic scale. In development, the absence of p53 impacted constitutive expression for a surprisingly broad scope of genes. By contrast, stim ...[more]

PMID: 17310982

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