Ontology highlight
ABSTRACT:
ORGANISM(S): Drosophila melanogaster
SUBMITTER: Ashley Wood
PROVIDER: E-GEOD-30740 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Wood Ashley M AM Van Bortle Kevin K Ramos Edward E Takenaka Naomi N Rohrbaugh Margaret M Jones Brian C BC Jones Keith C KC Corces Victor G VG
Molecular cell 20111001 1
Insulators are multiprotein-DNA complexes thought to affect gene expression by mediating inter- and intrachromosomal interactions. Drosophila insulators contain specific DNA-binding proteins plus common components, such as CP190, that facilitate these interactions. Here, we examine changes in the distribution of Drosophila insulator proteins during the heat-shock and ecdysone responses. We find that CP190 recruitment to insulator sites is the main regulatable step in controlling insulator functi ...[more]