Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Siavash Kurdistani
PROVIDER: E-GEOD-30738 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Marban Céline C Su Trent T Ferrari Roberto R Li Bing B Vatakis Dimitrios D Pellegrini Matteo M Zack Jerome A JA Rohr Olivier O Kurdistani Siavash K SK
PloS one 20111104 11
The HIV-1 Trans-Activator of Transcription (Tat) protein binds to multiple host cellular factors and greatly enhances the level of transcription of the HIV genome. While Tat's control of viral transcription is well-studied, much less is known about the interaction of Tat with the human genome. Here, we report the genome-wide binding map of Tat to the human genome in Jurkat T cells using chromatin immunoprecipitation combined with next-generation sequencing. Surprisingly, we found that ~53% of th ...[more]