Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Rossella Manfredini
PROVIDER: E-GEOD-30903 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Salvestrini Valentina V Zini Roberta R Rossi Lara L Gulinelli Sara S Manfredini Rossella R Bianchi Elisa E Piacibello Wanda W Caione Luisa L Migliardi Giorgia G Ricciardi Maria Rosaria MR Tafuri Agostino A Romano Marco M Salati Simona S Di Virgilio Francesco F Ferrari Sergio S Baccarani Michele M Ferrari Davide D Lemoli Roberto M RM
Blood 20111103 1
Extracellular ATP and UTP nucleotides increase the proliferation and engraftment potential of normal human hematopoietic stem cells via the engagement of purinergic receptors (P2Rs). In the present study, we show that ATP and UTP have strikingly opposite effects on human acute myeloblastic leukemia (AML) cells. Leukemic cells express P2Rs. ATP-stimulated leukemic cells, but not normal CD34+ cells, undergo down-regulation of genes involved in cell proliferation and migration, whereas cell-cycle i ...[more]