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Unknown,Transcriptomics,Genomics,Proteomics

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Integrated nuclear proteomics and transcriptomics identifies new high frequency dysregulated targets in acute myeloid leukemia

ABSTRACT: Acute myeloid leukemia (AML) is characterized by developmental arrest which is thought to arise from transcriptional dysregulation of myeloid development programs. Here, we have analyzed the transcriptome of AML blasts in comparison with normal human CD34+ cells using the HTA 2.0 gene chip. We have compared 18 minimally differentiated AML blasts with cord blood derived normal human CD34+ cells - this study is performed as a parallel analysis to compliment the nuclear proteomic studies.

ORGANISM(S): Homo sapiens

SUBMITTER: Alex Tonks

PROVIDER: E-MTAB-3873 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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