Hyperinfectivity study
Ontology highlight
ABSTRACT:
ORGANISM(S): Vibrio cholerae
SUBMITTER: Douglas Merrell
PROVIDER: E-GEOD-3104 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Host-induced epidemic spread of the cholera bacterium.
Merrell D Scott DS Butler Susan M SM Qadri Firdausi F Dolganov Nadia A NA Alam Ahsfaqul A Cohen Mitchell B MB Calderwood Stephen B SB Schoolnik Gary K GK Camilli Andrew A
Nature 20020601 6889
The factors that enhance the transmission of pathogens during epidemic spread are ill defined. Water-borne spread of the diarrhoeal disease cholera occurs rapidly in nature, whereas infection of human volunteers with bacteria grown in vitro is difficult in the absence of stomach acid buffering. It is unclear, however, whether stomach acidity is a principal factor contributing to epidemic spread. Here we report that characterization of Vibrio cholerae from human stools supports a model whereby hu ...[more]
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