Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Krishanpal Karmodiya
PROVIDER: E-GEOD-31052 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Molecular cell 20111101 3
Histone acetyltransferase (HAT) complexes are coactivators that are important for transcriptional activation by modifying chromatin. Metazoan SAGA and ATAC are distinct multisubunits complexes that share the same catalytic HAT subunit (GCN5 or PCAF). Here, we show that these human HAT complexes are targeted to different genomic loci representing functionally distinct regulatory elements both at broadly expressed and tissue-specific genes. While SAGA can principally be found at promoters, ATAC is ...[more]