Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Expression analysis of mutant U2AF35 transduced cells

ABSTRACT: In this study, to obtain the biological impact of the mutated U2AF35, HeLa and TF-1 cells were retrovirally transduced with either mock, wild-type or S34F mutant of U2AF35, and Expression array was performed. Expression analysis was performed for mock, wild-type U2AF35 or S34F mutant transduced HeLa and MDS-derived TF-1 cell line in triplicate.

ORGANISM(S): Homo sapiens

SUBMITTER: Aiko Sato-Otsubo

PROVIDER: E-GEOD-31172 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Frequent pathway mutations of splicing machinery in myelodysplasia.

Yoshida Kenichi K Sanada Masashi M Shiraishi Yuichi Y Nowak Daniel D Nagata Yasunobu Y Yamamoto Ryo R Sato Yusuke Y Sato-Otsubo Aiko A Kon Ayana A Nagasaki Masao M Chalkidis George G Suzuki Yutaka Y Shiosaka Masashi M Kawahata Ryoichiro R Yamaguchi Tomoyuki T Otsu Makoto M Obara Naoshi N Sakata-Yanagimoto Mamiko M Ishiyama Ken K Mori Hiraku H Nolte Florian F Hofmann Wolf-Karsten WK Miyawaki Shuichi S Sugano Sumio S Haferlach Claudia C Koeffler H Phillip HP Shih Lee-Yung LY Haferlach Torsten T Chiba Shigeru S Nakauchi Hiromitsu H Miyano Satoru S Ogawa Seishi S

Nature 20110911 7367

Myelodysplastic syndromes and related disorders (myelodysplasia) are a heterogeneous group of myeloid neoplasms showing deregulated blood cell production with evidence of myeloid dysplasia and a predisposition to acute myeloid leukaemia, whose pathogenesis is only incompletely understood. Here we report whole-exome sequencing of 29 myelodysplasia specimens, which unexpectedly revealed novel pathway mutations involving multiple components of the RNA splicing machinery, including U2AF35, ZRSR2, SR ...[more]

PMID: 21909114

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Dataset Information

Expression analysis of mutant U2AF35 transduced cells

Publications

Frequent pathway mutations of splicing machinery in myelodysplasia.

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