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Transcription profiling of human growing breast cancer cell lines

ABSTRACT: Gene expression analysis on growing breast cancer cell lines. Experiment Overall Design: see Bild, A. et.al.

ORGANISM(S): Homo sapiens

SUBMITTER: Joseph Nevins

PROVIDER: E-GEOD-3156 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Oncogenic pathway signatures in human cancers as a guide to targeted therapies.

Bild Andrea H AH Yao Guang G Chang Jeffrey T JT Wang Quanli Q Potti Anil A Chasse Dawn D Joshi Mary-Beth MB Harpole David D Lancaster Johnathan M JM Berchuck Andrew A Olson John A JA Marks Jeffrey R JR Dressman Holly K HK West Mike M Nevins Joseph R JR

Nature 20051106 7074

The development of an oncogenic state is a complex process involving the accumulation of multiple independent mutations that lead to deregulation of cell signalling pathways central to the control of cell growth and cell fate. The ability to define cancer subtypes, recurrence of disease and response to specific therapies using DNA microarray-based gene expression signatures has been demonstrated in multiple studies. Various studies have also demonstrated the potential for using gene expression p ...[more]

PMID: 16273092

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Transcription profiling of human growing breast cancer cell lines

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