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Variation in RNA expression in a panel of 30 breast cancer cell lines

ABSTRACT: RNA expression was measured using RNA sequencing in 30 different breast cancer cell lines, under untreated, exponentially growing conditions.

INSTRUMENT(S): Illumina HiSeq 2000

ORGANISM(S): Homo sapiens

SUBMITTER: Katarzyna Jastrzebski

PROVIDER: E-MTAB-4801 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Integrative Modeling Identifies Key Determinants of Inhibitor Sensitivity in Breast Cancer Cell Lines.

Jastrzebski Katarzyna K Thijssen Bram B Kluin Roelof J C RJC de Lint Klaas K Majewski Ian J IJ Beijersbergen Roderick L RL Wessels Lodewyk F A LFA

Cancer research 20180529 15

Cancer cell lines differ greatly in their sensitivity to anticancer drugs as a result of different oncogenic drivers and drug resistance mechanisms operating in each cell line. Although many of these mechanisms have been discovered, it remains a challenge to understand how they interact to render an individual cell line sensitive or resistant to a particular drug. To better understand this variability, we profiled a panel of 30 breast cancer cell lines in the absence of drugs for their mutations ...[more]

PMID: 29844118

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