Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Alexander Chervonsky
PROVIDER: E-GEOD-31726 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Varanasi Vineeth V Avanesyan Lia L Schumann Desiree M DM Chervonsky Alexander V AV
Diabetes 20120706 11
Several cytotoxic mechanisms have been attributed to T cells participating in β-cell death in type 1 diabetes. However, sensitivity of β-cells to these mechanisms in vitro and in vivo is likely to be different. Moreover, CD4⁺ and CD8⁺ T cells may use distinct mechanisms to cause β-cell demise that possibly involve activation of third-party cytotoxic cells. We used the transfer of genetically modified diabetogenic T cells into normal, mutant, and bone marrow chimeric recipients to test the contri ...[more]