Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Harrison Gabel
PROVIDER: E-GEOD-31849 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Neuron 20111001 1
Autism spectrum disorders such as Rett syndrome (RTT) have been hypothesized to arise from defects in experience-dependent synapse maturation. RTT is caused by mutations in MECP2, a nuclear protein that becomes phosphorylated at S421 in response to neuronal activation. We show here that disruption of MeCP2 S421 phosphorylation in vivo results in defects in synapse development and behavior, implicating activity-dependent regulation of MeCP2 in brain development and RTT. We investigated the mechan ...[more]