Transcription profiling of human tissue samples to identify novel genes associated with malignant melanoma but not benign melanocytic lesions
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
DISEASE(S): benign nevi
SUBMITTER: Tim Jatkoe
PROVIDER: E-GEOD-3189 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Novel genes associated with malignant melanoma but not benign melanocytic lesions.
Talantov Dmitri D Mazumder Abhijit A Yu Jack X JX Briggs Thomas T Jiang Yuqiu Y Backus John J Atkins David D Wang Yixin Y
Clinical cancer research : an official journal of the American Association for Cancer Research 20051001 20
<h4>Purpose</h4>Cutaneous melanoma is a common, aggressive cancer with increasing incidence. The identification of melanoma-specific deregulated genes could provide molecular markers for lymph node staging assays and further insight into melanoma tumorigenesis.<h4>Experimental design</h4>Total RNA isolated from 45 primary melanoma, 18 benign skin nevi, and 7 normal skin tissue specimens were analyzed on an Affymetrix Hu133A microarray containing 22,000 probe sets.<h4>Results</h4>Hierarchical clu ...[more]
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