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Downstream targets of Fgfrl1 signaling

ABSTRACT: Comparison of the gene expression profiles between normal and Fgfrl1 deficient kidneys 3 individual RNA preparations from 6-9 pooled normal kidneys each vs. 3 individual RNA preparations from 6-9 Fgfrl1-/- kidneys each

ORGANISM(S): Mus musculus

SUBMITTER: Beat Trueb

PROVIDER: E-GEOD-32013 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Comparison of the gene expression profiles from normal and Fgfrl1 deficient mouse kidneys reveals downstream targets of Fgfrl1 signaling.

Gerber Simon D SD Amann Ruth R Wyder Stefan S Trueb Beat B

PloS one 20120314 3

Fgfrl1 (fibroblast growth factor receptor-like 1) is a transmembrane receptor that is essential for the development of the metanephric kidney. It is expressed in all nascent nephrogenic structures and in the ureteric bud. Fgfrl1 null mice fail to develop the metanephric kidneys. Mutant kidney rudiments show a dramatic reduction of ureteric branching and a lack of mesenchymal-to-epithelial transition. Here, we compared the expression profiles of wildtype and Fgfrl1 mutant kidneys to identify gene ...[more]

PMID: 22432025

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