Unknown,Transcriptomics,Genomics,Proteomics

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Distinction between serous tumors of low malignant potential and serous carcinomas

ABSTRACT: OBJECTIVES: The molecular pathogenesis of ovarian serous tumors of low malignant potential (S-LMP) is not well understood, although the collective data suggest that they arise through molecular mechanisms distinct from those leading to conventional serous carcinomas (S-Ca). To further examine the molecular differences between these two diseases, we studied the gene expression pattern of ovarian S-LMP and S-Ca using high-density spotted cDNA and tissue microarrays. METHODS: Total RNA from 23 ovarian S-LMP and S-Ca was analyzed on 43,200 spot cDNA microarrays and the differential expression of proteins encoded by differentially expressed genes was validated using tissue microarrays. A clinical history design type is where the organisms clinical history of diagnosis, treatments, e.g. vaccinations, surgery etc. Computed

ORGANISM(S): Homo sapiens

SUBMITTER: Matt Van De Rijn

PROVIDER: E-GEOD-3208 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Distinction between serous tumors of low malignant potential and serous carcinomas based on global mRNA expression profiling.

Gilks C Blake CB Vanderhyden Barbara C BC Zhu Shirley S van de Rijn Matt M Longacre Teri A TA

Gynecologic oncology 20050301 3

<h4>Objectives</h4>The molecular pathogenesis of ovarian serous tumors of low malignant potential (S-LMP) is not well understood, although the collective data suggest that they arise through molecular mechanisms distinct from those leading to conventional serous carcinomas (S-Ca). To further examine the molecular differences between these two diseases, we studied the gene expression pattern of ovarian S-LMP and S-Ca using high-density spotted cDNA and tissue microarrays.<h4>Methods</h4>Total RNA ...[more]

PMID: 15721412

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Dataset Information

Distinction between serous tumors of low malignant potential and serous carcinomas

Publications

Distinction between serous tumors of low malignant potential and serous carcinomas based on global mRNA expression profiling.

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