Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Fiorentino 2006-7 dermatomyositis, lupus, control skin

ABSTRACT: Background: Dermatomyositis (DM) is an autoimmune disease that mainly affects the skin, muscle, and lung. The pathogenesis of skin inflammation in DM is not well understood. Methodology and Findings: We analyzed genome-wide expression data in DM skin and compared them to those from healthy controls. We observed a robust upregulation of interferon (IFN)-inducible genes in DM skin, as well as several other gene modules pertaining to inflammation, complement activation, and epidermal activation and differentiation. The interferon (IFN)-inducible genes within the DM signature were present not only in DM and lupus, but also cutaneous herpes simplex-2 infection and to a lesser degree, psoriasis. This IFN signature was absent or weakly present in atopic dermatitis, allergic contact dermatitis, acne vulgaris, systemic sclerosis, and localized scleroderma/morphea. We observed that the IFN signature in DM skin appears to be more closely related to type I than type II IFN based on in vitro IFN stimulation expression signatures. However, quantitation of IFN mRNAs in DM skin shows that the majority of known type I IFNs, as well as IFN gamma, are overexpressed in DM skin. In addition, both IFN-beta and IFN-gamma (but not other type I IFN) transcript levels were highly correlated with the degree of the in vivo IFN transcriptional response in DM skin. disease_state_design

ORGANISM(S): Homo sapiens

SUBMITTER: David Fiorentino

PROVIDER: E-GEOD-32245 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Interferon and biologic signatures in dermatomyositis skin: specificity and heterogeneity across diseases.

Wong David D Kea Bory B Pesich Rob R Higgs Brandon W BW Zhu Wei W Brown Patrick P Yao Yihong Y Fiorentino David D

PloS one 20120103 1

<h4>Background</h4>Dermatomyositis (DM) is an autoimmune disease that mainly affects the skin, muscle, and lung. The pathogenesis of skin inflammation in DM is not well understood.<h4>Methodology and findings</h4>We analyzed genome-wide expression data in DM skin and compared them to those from healthy controls. We observed a robust upregulation of interferon (IFN)-inducible genes in DM skin, as well as several other gene modules pertaining to inflammation, complement activation, and epidermal a ...[more]

PMID: 22235269

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Dataset Information

Fiorentino 2006-7 dermatomyositis, lupus, control skin

Publications

Interferon and biologic signatures in dermatomyositis skin: specificity and heterogeneity across diseases.

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