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FGFR1 target genes in brown adipose tissues

ABSTRACT: We aimed to identify genes that are regulated by FGFR1 in brown adipose tissues of adult male ob/ob mice by injecting 1 mg/kg anti-FGFR1 agonistic antibody. Brown adipose tissues were isolated from adult male ob/ob mice at day 4 after a single intraperitoneal injection of 1 mg/kg anti-FGFR1 agonistic antibody or pair-fed mice injected with control IgG. N=6 mice per each group.

ORGANISM(S): Mus musculus

SUBMITTER: Li Li

PROVIDER: E-GEOD-32316 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Amelioration of type 2 diabetes by antibody-mediated activation of fibroblast growth factor receptor 1.

Wu Ai-Luen AL Kolumam Ganesh G Stawicki Scott S Chen Yongmei Y Li Jun J Zavala-Solorio Jose J Phamluong Khanhky K Feng Bo B Li Li L Marsters Scot S Kates Lance L van Bruggen Nicholas N Leabman Maya M Wong Anne A West David D Stern Howard H Luis Elizabeth E Kim Hok Seon HS Yansura Daniel D Peterson Andrew S AS Filvaroff Ellen E Wu Yan Y Sonoda Junichiro J

Science translational medicine 20111201 113

Clinical use of recombinant fibroblast growth factor 21 (FGF21) for the treatment of type 2 diabetes and other disorders linked to obesity has been proposed; however, its clinical development has been challenging owing to its poor pharmacokinetics. Here, we describe an alternative antidiabetic strategy using agonistic anti-FGFR1 (FGF receptor 1) antibodies (R1MAbs) that mimic the metabolic effects of FGF21. A single injection of R1MAb into obese diabetic mice induced acute and sustained ameliora ...[more]

PMID: 22174314

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