Unknown,Transcriptomics,Genomics,Proteomics

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Methylation specifies distinct estrogen-induced binding site repertoires of CBP to chromatin


ABSTRACT: This SuperSeries is composed of the following subset Series: GSE32348: Methylation specifies distinct estrogen-induced binding site repertoires of CBP to chromatin (mRNA) GSE32349: Methylation specifies distinct estrogen-induced binding site repertoires of CBP to chromatin (ChIP-Seq) Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Marco Antonio Mendoza-Parra 

PROVIDER: E-GEOD-32350 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Methylation specifies distinct estrogen-induced binding site repertoires of CBP to chromatin.

Ceschin Danilo Guillermo DG   Walia Mannu M   Wenk Sandra Simone SS   Duboé Carine C   Gaudon Claudine C   Xiao Yu Y   Fauquier Lucas L   Sankar Martial M   Vandel Laurence L   Gronemeyer Hinrich H  

Genes & development 20110601 11


Multiple signaling pathways ultimately modulate the epigenetic information embedded in the chromatin of gene promoters by recruiting epigenetic enzymes. We found that, in estrogen-regulated gene programming, the acetyltransferase CREB-binding protein (CBP) is specifically and exclusively methylated by the coactivator-associated arginine methyltransferase (CARM1) in vivo. CARM1-dependent CBP methylation and p160 coactivators were required for estrogen-induced recruitment to chromatin targets. Not  ...[more]

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