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Control vs Diabetic mice skeletal muscle miRNA microarray

ABSTRACT: To extract the differentially expressed miRNA between control vs diabetic mice skeletal muscle. We used obese diabetic (C57BL/KsJ db/db) and normal control (C57BL/KsJ db+) mice, which were obtained from the Animal House Facility of the Central Drug Research Institute (CSIR), Lucknow, India.

ORGANISM(S): Mus musculus

SUBMITTER: Malabika Datta

PROVIDER: E-GEOD-32376 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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miR-135a targets IRS2 and regulates insulin signaling and glucose uptake in the diabetic gastrocnemius skeletal muscle.

Agarwal Priyanka P Srivastava Rohit R Srivastava Arvind K AK Ali Shakir S Datta Malabika M

Biochimica et biophysica acta 20130408 8

Although aberrant miRNA signatures are associated with diabetes, yet, the status and role of altered miRNAs in the diabetic skeletal muscle is currently poorly understood. Here, we report that 41 miRNAs are altered in the diabetic gastrocnemius skeletal muscle and of these, miR-135a that is identified as a critical regulator of myogenesis, is significantly up-regulated. IRS2 is predicted as its potential putative target and its levels are down-regulated in the diabetic gastrocnemius skeletal mus ...[more]

PMID: 23579070

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