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Comparison between cell lines from 9 different cancer tissue (NCI-60) (Affymetrix U133 Plus 2.0)

ABSTRACT: Comparison between cell lines from 9 different cancer tissue of origin types (Breast, Central Nervous System, Colon, Leukemia, Melanoma, Non-Small Cell Lung, Ovarian, Prostate, Renal) from NCI-60 panel. Cell lines from 9 different cancer tissue of origin types

ORGANISM(S): Homo sapiens

SUBMITTER: Sudhir Varma 

PROVIDER: E-GEOD-32474 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Topoisomerase I levels in the NCI-60 cancer cell line panel determined by validated ELISA and microarray analysis and correlation with indenoisoquinoline sensitivity.

Pfister Thomas D TD   Reinhold William C WC   Agama Keli K   Gupta Shalu S   Khin Sonny A SA   Kinders Robert J RJ   Parchment Ralph E RE   Tomaszewski Joseph E JE   Doroshow James H JH   Pommier Yves Y  

Molecular cancer therapeutics 20090707 7

Topoisomerase I (Top1) is a proven target for cancer therapeutics, and the level of Top1 in tumors has been used as a biomarker for chemotherapeutic efficacy. In this study, we report the development and validation of a two-site enzyme chemiluminescent immunoassay for Top1, which we used to measure Top1 levels in the NCI-60 cancer cell line panel. Top1 levels ranged from 0.9 to 9.8 ng/mL/microg protein extract in these cell lines. Levels varied both within and between cancer types but were gener  ...[more]

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