Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: TAKAYUKI IWAMOTO
PROVIDER: E-GEOD-32518 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Bianchini Giampaolo G Qi Yuan Y Alvarez Ricardo H RH Iwamoto Takayuki T Coutant Charles C Ibrahim Nuhad K NK Valero Vicente V Cristofanilli Massimo M Green Marjorie C MC Radvanyi Laszlo L Hatzis Christos C Hortobagyi Gabriel N GN Andre Fabrice F Gianni Luca L Symmans W Fraser WF Pusztai Lajos L
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20100830 28
<h4>Purpose</h4>The purpose of this study was to identify genes enriched in breast cancer stroma, assess the stromal gene expression differences between estrogen receptor (ER) -positive and -negative cancers, and separately determine their prognostic value in these two subtypes of breast cancers.<h4>Methods</h4>We compared gene expression profiles of pairs of fine-needle (stroma-poor) and core-needle (stroma-rich) biopsies from 37 cancers to identify stroma-associated genes. We defined stromal m ...[more]