Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Transcription profiling of diaphragm muscles from alpha2-laminin (merosin)-deficient dy/dy dystrophic mice and wild type mice to study differential gene expression.


ABSTRACT: Laminin (merosin) deficient muscular dystrophy in dy/dy mouse diaphragm muscle, 8 weeks old Experiment Overall Design: 4 normal samples; 4 dystrophic samples; Each sample consists of muscle pooled from 3 mice, thus a total of 12 normal and 12 dystrophic mice were studied

ORGANISM(S): Mus musculus

DISEASE(S): reference

SUBMITTER: Erik -- van Lunteren 

PROVIDER: E-GEOD-3252 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

altmetric image

Publications

Gene expression profiling of diaphragm muscle in alpha2-laminin (merosin)-deficient dy/dy dystrophic mice.

van Lunteren Erik E   Moyer Michelle M   Leahy Patrick P  

Physiological genomics 20051220 1


Deficiency of alpha2-laminin (merosin) underlies classical congenital muscular dystrophy in humans and dy/dy muscular dystrophy in mice and causes severe muscle dysfunction in both species. To gain greater insight into the biochemical and molecular events that link alpha2-laminin deficiency with muscle fiber necrosis, and the associated compensatory responses, gene expression profiles were characterized in diaphragm muscle from 8-wk-old dy/dy mice using oligonucleotide microarrays. Compared with  ...[more]

Similar Datasets

2006-03-16 | GSE3252 | GEO
2012-12-21 | E-GEOD-21219 | biostudies-arrayexpress
2012-12-21 | GSE21219 | GEO
2015-11-25 | E-GEOD-21498 | biostudies-arrayexpress
| PRJNA92901 | ENA
2011-12-08 | GSE25258 | GEO
2011-12-08 | E-GEOD-25258 | biostudies-arrayexpress
2019-09-26 | E-MTAB-7698 | biostudies-arrayexpress
2004-08-10 | GSE1636 | GEO
2004-08-10 | E-GEOD-1636 | biostudies-arrayexpress