Influence of cell permeable Tre-recombinase (CPTR) treatment on T-cell gene expression
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Nicole Walz
PROVIDER: E-GEOD-32643 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Excision of HIV-1 proviral DNA by recombinant cell permeable tre-recombinase.
Mariyanna Lakshmikanth L Priyadarshini Poornima P Hofmann-Sieber Helga H Krepstakies Marcel M Walz Nicole N Grundhoff Adam A Buchholz Frank F Hildt Eberhard E Hauber Joachim J
PloS one 20120213 2
Over the previous years, comprehensive studies on antiretroviral drugs resulted in the successful introduction of highly active antiretroviral therapy (HAART) into clinical practice for treatment of HIV/AIDS. However, there is still need for new therapeutic approaches, since HAART cannot eradicate HIV-1 from the infected organism and, unfortunately, can be associated with long-term toxicity and the development of drug resistance. In contrast, novel gene therapy strategies may have the potential ...[more]
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