Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Oxidative burden and mitochondrial dysfunction in a mouse model of Rett syndrome

ABSTRACT: To identify the detailed molecular causes of the mitochondrial dysfunction, oxidative burden and more vulnerable redox balance in Rett mouse hippocampus, we screened for differential gene expression in the hippocampal CA1 subfield of adult male mice. A whole mouse genome microarray was performed to assess, whether key enzymes of the mitochondrial respiratory chain or major cellular radical scavenging enzymes are affected in this MeCP2-deficient mouse model of Rett syndrome. Comparison of gene expression between male wildtype mice (Mecp2+/y) and mice lacking the MECP2 gene (Mecp2-/y) [B6.129P2(C)-Mecp2tm-1-1Bird (Guy et al. 2001, Nat. Genet. 27: 322-326)]. In total, 9 mice of each genotype were analyzed. The mRNA of groups of 3 animals was pooled to generate 3 independent biological samples, and finally three microarrays were run for each genotype.

ORGANISM(S): Mus musculus

SUBMITTER: Lennart Opitz 

PROVIDER: E-GEOD-32870 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Json Xml
altmetric image

Publications

Rett syndrome is an X chromosome-linked neurodevelopmental disorder associated with cognitive impairment, motor dysfunction and breathing irregularities causing intermittent hypoxia. Evidence for impaired mitochondrial function is also accumulating. A subunit of complex III is among the potentially dys-regulated genes, the inner mitochondrial membrane is leaking protons, brain ATP levels seem reduced, and Rett patient blood samples confirm increased oxidative damage. We therefore screened for mi  ...[more]

Similar Datasets

Transcriptomics Oxidative burden and mitochondrial dysfunction in a mouse model of Rett syndrome
2012-08-31 | GSE32870 | GEO
Transcriptomics Systemic Transcriptional Phenotypes in Mecp2 Null Mice
2021-09-01 | GSE140054 | GEO
Proteomics MeCP2 heterochromatin organization is modulated by arginine methylation and serine phosphorylation
2022-10-15 | PXD033696 | Pride
Transcriptomics Transcriptome analysis of a MECP2 conditional KO mouse model
2018-04-05 | GSE112663 | GEO
Transcriptomics TAp73 is a trophic factor essential for sperm cell adhesion and maturation in testis
2013-12-31 | E-GEOD-46034 | biostudies-arrayexpress
Transcriptomics Cell type specific expression data from Mecp2 null mice
2011-11-01 | E-GEOD-8720 | biostudies-arrayexpress
Transcriptomics Genome-wide Analysis Reveals Mecp2-dependent Regulation of MicroRNAs in a Mouse Model of Rett Syndrome
2010-09-29 | E-GEOD-24329 | biostudies-arrayexpress
Transcriptomics Dynamic dysregulation of the transcriptome upon deletion of Mecp2 in adult mice
2024-12-16 | GSE246119 | GEO
Transcriptomics TAp73 is essential for germ cell adhesion and maturation in testis
2014-03-07 | E-GEOD-52124 | biostudies-arrayexpress
Transcriptomics Swapping the DNA binding domain of MeCP2 with that of MBD2 to abolish binding to non-CG methlyation results in RTT-like phenotypes in mice [RNA-seq]
2021-02-07 | GSE152800 | GEO