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Using DNA methylation to detect dysplasia/early neoplasia in Barrett's carcinogenesis

ABSTRACT: Dysplasia and early cancer are hard to detect in endoscopic biopsies and hence this study was carried out to evaluate the biomarker potential of DNA methylation to detect dyspasia and early cancer in Barrett's esophaghus patients. Bisulfite converted genomic DNA was hybridized onto Illumina 27k methylation arrays. 22 Barrett's esophagus (BE) and 2 Duodenum vs. 24 esophageal adenocarcinoma (EAC)

ORGANISM(S): Homo sapiens

SUBMITTER: Muhammad Alvi 

PROVIDER: E-GEOD-32925 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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DNA methylation as an adjunct to histopathology to detect prevalent, inconspicuous dysplasia and early-stage neoplasia in Barrett's esophagus.

Alvi Muhammad A MA   Liu Xinxue X   O'Donovan Maria M   Newton Richard R   Wernisch Lorenz L   Shannon Nicholas B NB   Shariff Kareem K   di Pietro Massimiliano M   Bergman Jacques J G H M JJ   Ragunath Krish K   Fitzgerald Rebecca C RC  

Clinical cancer research : an official journal of the American Association for Cancer Research 20121214 4

<h4>Purpose</h4>Endoscopic surveillance of Barrett's esophagus is problematic because dysplasia/early-stage neoplasia is frequently invisible and likely to be missed because of sampling bias. Molecular abnormalities may be more diffuse than dysplasia. The aim was therefore to test whether DNA methylation, especially on imprinted and X-chromosome genes, is able to detect dysplasia/early-stage neoplasia.<h4>Experimental design</h4>27K methylation arrays were used to find genes best able to differe  ...[more]

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