Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Muhammad Alvi
PROVIDER: E-GEOD-32925 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Clinical cancer research : an official journal of the American Association for Cancer Research 20121214 4
<h4>Purpose</h4>Endoscopic surveillance of Barrett's esophagus is problematic because dysplasia/early-stage neoplasia is frequently invisible and likely to be missed because of sampling bias. Molecular abnormalities may be more diffuse than dysplasia. The aim was therefore to test whether DNA methylation, especially on imprinted and X-chromosome genes, is able to detect dysplasia/early-stage neoplasia.<h4>Experimental design</h4>27K methylation arrays were used to find genes best able to differe ...[more]