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Global transcriptome analysis of mammary tissue during fetal bud formation and growth in two pig breeds

ABSTRACT: The mammary gland development in swine begins at embryogenesis. The number and identity of relevant genes are unknown. Simultaneously, 24,123 probe-sets were screened, of which some 12,000 had present calls and were analysed for differential expression between different breeds (german landrace and pietrain) at different stages of development ( 63 and 91 dpc) RNAs of teat from german landrace and pietrain at 63 and 91 dpc were hybridized to Affymetrix Porcine Genome Arrays.

ORGANISM(S): Sus scrofa

SUBMITTER: Klaus Wimmers

PROVIDER: E-GEOD-32956 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Global transcriptome analysis of mammary tissue during fetal bud formation and growth in two pig breeds

Project description:The mammary gland development in swine begins at embryogenesis. The number and identity of relevant genes are unknown. Simultaneously, 24,123 probe-sets were screened, of which some 12,000 had present calls and were analysed for differential expression between different breeds (german landrace and pietrain) at different stages of development ( 63 and 91 dpc)

2012-12-31 | GSE32956 | GEO

Gene expression data of mRNA from skeletal muscle sample of pig DL and Pi breed

Project description:The skeletal muscle development in swine begins at embryogenesis. Simultaneously, 24,123 probe-sets were screened, analysed for differential expression between different breeds (german landrace and pietrain) at different stages of development (35, 63, 91 dpc and adult stage). RNAs of skeletal muscle from german landrace and pietrain at 35, 63, 91 dpc and adult stages were hybridized to Affymetrix GeneChip Porcine Genome Array.

2013-11-01 | E-GEOD-38518 | biostudies-arrayexpress

Gene expression data of micro RNA from skeletal muscle sample of pig DL and Pi breed

Project description:Total of 675 porcine miRNA candidates datasets revealed by 100% aligment homologs and review literatures publication. Probe-sets were screened, analysed for differential expression between different breeds (german landrace and pietrain) at different stages of development (63, 91 dpc and adult stage) microRNAs of skeletal muscle from german landrace and pietrain at 63, 91 dpc and adult stages were hybridized to Affymetrix GeneChip miRNA arrays.

2013-01-19 | E-GEOD-34213 | biostudies-arrayexpress

Gene expression data of mRNA from skeletal muscle sample of pig DL and Pi breed

2013-11-01 | GSE38518 | GEO

Gene expression data of micro RNA from skeletal muscle sample of pig DL and Pi breed

2013-01-19 | GSE34213 | GEO

Pre- and postnatal hepatic expression profiles of two pig breeds differing in body composition

Project description:In order to gain insight into hepatic metabolic pathways and key transcripts affecting traits related to body composition we aimed to compare samples of pigs of two breeds, the âobeseâ German Landrace (DL) and the âleanâ Pietrain (Pi) obtained at prenatal stages (35, 63, and 91 days post conceptionem) and at adult age (180 days). In terms of number of genes regulated the most striking differences between DL and Pi were found at adult age with upregulation of key genes of lipid biosynthesis/metabolism pathways (FASN, ACSS2, ACACA) in obese DL pigs on the one hand and upregulation of genes of cell growth and/or maintenance, protein syntheses as well as cell proliferation pathways (PPARD, POU1F1, IGF2R) in lean Pi pigs on the other hand. Time course analysis of expression profiles of breed differences from foetal to adult stage and functional cluster analysis of the biological processes confirmed the trend of differences between genetically different obese and lean breeds. The highlighted classes of genes showed common breed-typical expression throughout prenatal development and at adult age. The transcriptional differences between obese and lean pigs involving lipid pathways and cell activity are already initiated during early prenatal development. The information about genetic differences between obese and lean pigs reveals a number of functional candidate genes for traits related to obesity and leaness. Porcine liver from three prenatal stages (35, 63, and 91 day post conceptionem, dpc) plus adult age (180 days) of 10 animals of each of the breeds DL and Pi, which differ in body composition, were collected. The hepatic gene expression patterns of DL and Pi breeds were compared at each of the four stages of development. Three or four biological replicate microarray hybridisations were performed for each stage with DL pools labelled with Cy5 and Pi pools labelled with Cy3.

2010-06-30 | E-GEOD-5399 | biostudies-arrayexpress

Fetal programming of liver transcriptome in response to gestational diets varying in methylating micronutrients in pigs

Project description:Pietrain gilts were fed a control diet (CON) or a methyl-enriched diet (MET) throughout their pregnancy. Liver transcriptome profiles of the offspring were analyzed at prenatal stages [35, 63, 91 days post-conception (dpc)].

2015-06-01 | GSE59299 | GEO

Pre- and postnatal hepatic expression profiles of two pig breeds differing in body composition

Project description:In order to gain insight into hepatic metabolic pathways and key transcripts affecting traits related to body composition we aimed to compare samples of pigs of two breeds, the “obese” German Landrace (DL) and the “lean” Pietrain (Pi) obtained at prenatal stages (35, 63, and 91 days post conceptionem) and at adult age (180 days). In terms of number of genes regulated the most striking differences between DL and Pi were found at adult age with upregulation of key genes of lipid biosynthesis/metabolism pathways (FASN, ACSS2, ACACA) in obese DL pigs on the one hand and upregulation of genes of cell growth and/or maintenance, protein syntheses as well as cell proliferation pathways (PPARD, POU1F1, IGF2R) in lean Pi pigs on the other hand. Time course analysis of expression profiles of breed differences from foetal to adult stage and functional cluster analysis of the biological processes confirmed the trend of differences between genetically different obese and lean breeds. The highlighted classes of genes showed common breed-typical expression throughout prenatal development and at adult age. The transcriptional differences between obese and lean pigs involving lipid pathways and cell activity are already initiated during early prenatal development. The information about genetic differences between obese and lean pigs reveals a number of functional candidate genes for traits related to obesity and leaness. Keywords: pig, oligo-microarray, prenatal liver expression, adult liver expression, obesity, leaness

2007-07-27 | GSE5399 | GEO

Fetal programming of muscle transcriptome in response to gestational dietary protein levels in the pig [LP]

Project description:German landrace gilts were fed a low protein diet (LP, 6% CP) throughout their whole pregnancy. Subsequently muscle transcriptome profiles of the offspring were analysed at prenatal (94 dpc) and postnatal stages (1, 28, 188 dpn)

2012-09-05 | GSE33739 | GEO

Fetal programming of muscle transcriptome in response to gestational dietary protein levels in the pig [HP]

Project description:German landrace gilts were fed a high protein diet (HP, 30% CP) throughout their whole pregnancy. Subsequently muscle transcriptome profiles of the offspring were analysed at prenatal (94 dpc) and postnatal stages (1, 28, 188 dpn)

2012-09-05 | GSE33738 | GEO

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