Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: David Finkelstein
PROVIDER: E-GEOD-33200 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Kawauchi Daisuke D Robinson Giles G Uziel Tamar T Gibson Paul P Rehg Jerold J Gao Cuilan C Finkelstein David D Qu Chunxu C Pounds Stanley S Ellison David W DW Gilbertson Richard J RJ Roussel Martine F MF
Cancer cell 20120201 2
Medulloblastomas that display a large cell/anaplastic morphology and overexpress the cellular c-MYC gene are highly aggressive and carry a very poor prognosis. This so-called MYC-subgroup differs in its histopathology, gene expression profile, and clinical behavior from other forms of medulloblastoma. We generated a mouse model of MYC-subgroup medulloblastoma by transducing Trp53-null cerebellar progenitor cells with Myc. The cardinal features of these mouse medulloblastomas closely mimic those ...[more]