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Affymetrix SNP array data for acute T-cell leukemia/lymphoma (ATL)

ABSTRACT: SNP array analysis was performed using 168 ATL specimens. To obtain genotypes and intensities for each SNP, Affymetrix 250K SNP arrays were performed for 168 ATL samples.

ORGANISM(S): Homo sapiens

SUBMITTER: Aiko Sato-Otsubo

PROVIDER: E-GEOD-33602 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Polycomb-mediated loss of miR-31 activates NIK-dependent NF-κB pathway in adult T cell leukemia and other cancers.

Yamagishi Makoto M Nakano Kazumi K Miyake Ariko A Yamochi Tadanori T Kagami Yayoi Y Tsutsumi Akihisa A Matsuda Yuka Y Sato-Otsubo Aiko A Muto Satsuki S Utsunomiya Atae A Yamaguchi Kazunari K Uchimaru Kaoru K Ogawa Seishi S Watanabe Toshiki T

Cancer cell 20120101 1

Constitutive NF-κB activation has causative roles in adult T cell leukemia (ATL) caused by HTLV-1 and other cancers. Here, we report a pathway involving Polycomb-mediated miRNA silencing and NF-κB activation. We determine the miRNA signatures and reveal miR-31 loss in primary ATL cells. MiR-31 negatively regulates the noncanonical NF-κB pathway by targeting NF-κB inducing kinase (NIK). Loss of miR-31 therefore triggers oncogenic signaling. In ATL cells, miR-31 level is epigenetically regulated, ...[more]

PMID: 22264793

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