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The downstream gene expression of AnxA4 in AGS cells

ABSTRACT: AnxA4 expression is increased in H. pylori associated tumors. Moreover, in renal-cell cancer, AnxA4 increases tumor cell dissemination and promotes cell migration, and in colorectal cancer, it is identified as a potential diagnostic marker. How AnxA4 might be involved in tumorgenesis has remained unclear. Here, we compared the gene expression profiles between the cells transfected with pcDNA3.1 (+)/AnxA4 and control (empty vector) to study the downstream genes of AnxA4 using Exon array technique. Four samples are analyzed.

ORGANISM(S): Homo sapiens

SUBMITTER: Hsueh-Fen Juan

PROVIDER: E-GEOD-33620 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Revealing the molecular mechanism of gastric cancer marker annexin A4 in cancer cell proliferation using exon arrays.

Lin Li-Ling LL Huang Hsuan-Cheng HC Juan Hsueh-Fen HF

PloS one 20120907 9

Gastric cancer is a malignant disease that arises from the gastric epithelium. A potential biomarker for gastric cancer is the protein annexin A4 (ANXA4), an intracellular Ca(2+) sensor. ANXA4 is primarily found in epithelial cells, and is known to be involved in various biological processes, including apoptosis, cell cycling and anticoagulation. In respect to cancer, ANXA4-overexpression has been observed in cancers of various origins, including gastric tumors associated with Helicobacter pylor ...[more]

PMID: 22970268

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The downstream gene expression of AnxA4 in AGS cells

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