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Huntingtin contains an ubiquitin-binding domain and regulates lysosomal targeting of mitochondrial and RNA-binding proteins

ABSTRACT: Evaluating the identity of ubiquitinated and ubiquitin-associated proteins tandem co-purifying non-covalently with wild-type (17 glutamine) human Huntingtin fragment, amino acids 1-502 C-terminally tagged with the HA peptide epitope, basally expressed from the CMV promoter within vector pcDNA3.1 transiently transfected into striatal precursor cell line St14A, significantly elevated above cells transfected with empty pcDNA3.1 vector negative control, in cells co-transfected with human FLAG-ubiquitin.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Clinton Yu

LAB HEAD: Joan S. Steffan

PROVIDER: PXD053980 | Pride | 2024-07-31

REPOSITORIES: Pride

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			Action	DRS
	JS_OrbitrapLUMOS_20200612_01_ITMSms2hcd.txt	Txt
	JS_OrbitrapLUMOS_20200612_01_V.raw	Raw
	JS_OrbitrapLUMOS_20200612_05_502.raw	Raw
	JS_OrbitrapLUMOS_20200612_05_ITMSms2hcd.txt	Txt
	JS_OrbitrapLUMOS_20210322_03_502_1.raw	Raw

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