Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Baoxu Pang
PROVIDER: E-GEOD-33624 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Nature communications 20130101
DNA topoisomerase II inhibitors are a major class of cancer chemotherapeutics, which are thought to eliminate cancer cells by inducing DNA double-strand breaks. Here we identify a novel activity for the anthracycline class of DNA topoisomerase II inhibitors: histone eviction from open chromosomal areas. We show that anthracyclines promote histone eviction irrespective of their ability to induce DNA double-strand breaks. The histone variant H2AX, which is a key component of the DNA damage respons ...[more]