Distinct effects of topoisomerase II inhibitors on tumor cell lines (part 1)
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ABSTRACT: One major class of anti-cancer drugs targets topoisomerase II to induce DNA double-strand breaks and cell death of fast growing cells. Here, we compare three members of this class - the antracyclines doxorubicin and aclarubicin, and a chemically unrelated compound, etoposide. Aclarubicin does not induce DNA breaks. We define a new activity for the antracyclines: unsupported histone eviction from ´open´ or loosely packed chromosomal areas reflecting exon and promoter regions. As a result, the epigenome and the transcriptome are strongly affected.
ORGANISM(S): Homo sapiens
PROVIDER: GSE33624 | GEO | 2013/06/04
SECONDARY ACCESSION(S): PRJNA154321
REPOSITORIES: GEO
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