Selective Functions of Individual Zinc Fingers Within the DNA-Binding Domain of Ikaros
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Hilde Schjerven
PROVIDER: E-GEOD-33693 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Selective regulation of lymphopoiesis and leukemogenesis by individual zinc fingers of Ikaros.
Schjerven Hilde H McLaughlin Jami J Arenzana Teresita L TL Frietze Seth S Cheng Donghui D Wadsworth Sarah E SE Lawson Gregory W GW Bensinger Steven J SJ Farnham Peggy J PJ Witte Owen N ON Smale Stephen T ST
Nature immunology 20130908 10
C2H2 zinc fingers are found in several key transcriptional regulators in the immune system. However, these proteins usually contain more fingers than are needed for sequence-specific DNA binding, which suggests that different fingers regulate different genes and functions. Here we found that mice lacking finger 1 or finger 4 of Ikaros exhibited distinct subsets of the hematological defects of Ikaros-null mice. Most notably, the two fingers controlled different stages of lymphopoiesis, and finger ...[more]
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